Compare Products: Select up to 4 products. Table 3. In a further study (White, 1987) sheep were treated with a pour-on application at either 0.01 g/kg BW or twice this dose (see Table 2). The WHO Recommended Classification of Pesticides by Hazard identifies alpha-cypermethrin (technical grade) as Class II: moderately hazardous; Main Use: insecticide. HRC report SLL 240/920997. Radiolabeled depletion studies in dairy cattle using 14C-Alphacypermethrin pour-on applications. Chemical Review Manager: Dana Friedman, (friedman.dana@epa.gov), 703-347-8827 Press Contact: Dale Kemery (kemery.dale@epa.gov), 202-564-4355 Docket Information. It is widely used in agricultural crops, forestry as well as in public and animal health. Cypermethrin is toxic to the nervous system. Only in the subcutaneous fat of one cow slaughtered at 35 days post dosing was a residue measured at the LOQ of 30 m g/kg. Cypermethrin typically contains 20-40% alpha-cypermethrin. The results for the pour-on veterinary drug preparation are more applicable for the evaluations by JECFA. Total residues of radiolabeled alphacypermethrin in milk after a pour-on application. It is widely used in agricultural crops, forestry as well as in public and animal health. Alpha cypermethrin is a pyrethroid insecticide consisting essentially of two of the four cisisomers comprising cypermethrin. specifications for alpha-cypermethrin alpha-cypermethrin information 6 alpha-cypermethrin long-lasting (incorporated into filaments) insecticidal net (october 2014) 7 part two evaluations of alpha-cypermethrin 2014.1 fao/who evaluation report on alpha-cypermethrin long-lasting (incorporated into filaments) insecticidal net 12 annex 1: references 13 Recoveries were between 80 and 105 %. /alpha-Cypermethrin/ WHO International Programme on Chemical Safety; The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2009 p.26 (2010) Two tentative values of 16 % in liver and 20 % in kidney were determined in one cow treated orally. In the milk samples following the pour-on application, total radioactivity mean levels rose to 7 m g/l by day 2 with the range < 1-12 m g/l for the individual animals. After oral dosing of 14C-alphacypermethrin to one lactating cow (see above), residue concentrations (g equiv/kg) were found in: muscle 19-29: liver, 560: kidney, 220: fat, 390-480: milk (up to 200) (Morrison and Richardson, 1994). Calves, aged 4-5 months, were dosed with 0.15 g of the pour-on preparation of alphacypermethrin and residues were determined in tissue samples by GC-ECD (LOQ 10 m g/kg) (Redgrave et al., 1992). Only the results are submitted. Muscle, fat and milk contained mainly a single component (muscle 85 %, fat 91 % and milk 97 % of the extract profile), which in each case had similar chromatographic properties to alphacypermethrin. 346a(e), proposed revisions to existing tolerances for the insecticide alpha-cypermethrin to reduce the allowable levels of the pesticide in or on fruit, citrus, group 10-10 from 10 parts per million (ppm) to 0.35 ppm and in Start Printed Page 25942 or on hog, fat from 1.0 ppm to … IDENTIFICATION: Alpha-cypermethrin is a highly active pyrethroid insecticide, effective against a wide range of pests encountered in agriculture and animal husbandry. The maximum value was 5 m g/l on the 2nd and 4th day after treating with the highest dose. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. Over an eight day collection period 50-60% of the dose was excreted in the urine and 30-40% in the faeces. The solvent was evaporated and the residue redissolved in hexane. Alpha-cypermethrin, cypermethrin, and zeta-cypermethrin are all pyrethroid insecticides and are isomer mixtures of the same chemical. The limit of detection is 10 m g/kg although no validation data other than for recoveries were provided (SAMS 461-1). Confirmation was by combined gas chromatography mass spectrometry (GC-MS) monitoring the ions 207 and 209 in the negative ion chemical ionization mode. Alpha-cypermethrin is a broad-spectrum type II pyrethroid restricted use pesticide that is registered for use on soybeans, corn, vegetables, sugar beets, wheat, alfalfa and other minor crops. Method SAMS 461-1 is a GC method to determine alphacypermethrin residues in animal tissues (liver, kidney, muscle and fat). and Gillis, N.A., (1993). Add to Cart | Add to Compare Metabolism and elimination of 14C-aryl-labelled cis and trans isomers in rats. The values are the ranges with the mean values in brackets. Best results will be obtained by spraying at egg hatch. Liver and kidney contained a range of components. The Committee recommends temporary MRLs for cattle, sheep and chickens of 100 m g/kg in muscle, liver and kidney, 500 m g/kg in fat, 25 m g/l for cows whole milk and 50 m g/kg for eggs expressed as parent drug. The only possible option for a marker substance is the parent compound, alphacypermethrin. 8. Determination of Residues of Alphacypermethrin in Animal Tissue. Alpha-cypermethrin is the only non-selective knock down insecticide registered for the purpose of spraying insects in Blue Gum plantations. In a poultry study, hens were treated with an alphacypermethrin spray and residues in eggs measured over a 14 day period. State Availability Yes No Not Specified This information is for reference only. This was different from the trans isomers where the excretion was virtually complete within 72 hours (Crawford and Hutson, 1977). Residues of alphacypermethrin (m g/kg) in sheep fat 7 days after treatment with pour-on applications of alphacypermethrin. Archives of Toxicology, 67, 510-513. For edible tissues fat is the first choice for a marker tissue. It can be used as a protective agent when applied at regular intervals or as a knockdown treatment to control existing larvae. The 14C-metabolites in urine (72-96 h after initial dosing) were characterised by co-chromatography using HPLC and TLC. Cypermethrin is an insecticide used both in agricultural and non-agricultural settings. • Cypermethrin Fact Sheet - National Pesticide Information Center Washington, D.C. 7. After the application of the pour-on preparation no residues were detectable in the muscle and liver of young cattle and were < 30 m g/kg in kidney over the 14 day post dosing period. In one study with the pour-on treatment, residues in fat were not detectable within 7 days of dosing but in sheep which were dipped the residues were 40 m g/kg in fat at 7 and 14 days after dosing. Sheep which were dipped in a preparation of alphacypermethrin had higher residues in the fat, wool and skin than those receiving the pour-on application. Whilst its chemical properties suggest that it should not leach to groundwater it has been detected. It is considered a serious marine pollutant. Sherren, A.J., (1988a). Once receive your question, the supplier will answer you as soon as possible. Method was used to determine alphacypermethrin residues in these tissues, nor in skin the ranges the! Milk or milk fat are suitable for monitoring milk and eggs low Volumen 160mL/ha High Volume 3... The slower hydrolysis of the total administered radioactivity was excreted within 48 hours followed by confirmation GC-MS... 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